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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically focused on the practical aspects of the research design, like recruitment and consent in adherence, as well as the use of commonly available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and included participants from different geographic areas. This type of heterogeneity, that is crucial for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity, can cause problems with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be a great method of determining the causality between an intervention and its results. They should not, however be used to replace explanatory studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also proposed a framework for pragmatic trials, 프라그마틱 무료 슬롯버프 무료 (please click the following post) which they called PRECIS.2 This tool was designed to define the elements of a pragmatic study that include the recruitment process, the design and delivery of the intervention, as well as follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.